Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 4/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358219 | 0.93 | TRPM8 (0.52) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL16801567 | 0.91 | HTR2C (0.56) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL26863407 | 0.90 | TRPM8 (0.56) | SLC6A4HTR1ATRPM8KDM4EMAPT | |
| SCHEMBL5363538 | 0.85 | CYP1A2 (0.60) | HTR1ATRPM8KDM4EMAPTHTR6 | |
| SCHEMBL8876508 | 0.83 | HTR6 (0.55) | HTR2CADRB2SLC6A4HTR1AHTR6 | |
| SCHEMBL15956252 | 0.82 | TRPM8 (0.62) | SLC6A4HTR1ATRPM8KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9031803 | 0.82 | OPRM1 (0.55) | SLC6A4HTR1ATRPM8KDM4EMAPT | |
| SCHEMBL5705170 | 0.81 | KDM4E (0.62) | SLC6A4HTR1ATRPM8KDM4EMAPT | |
| SCHEMBL15966299 | 0.80 | TRPM8 (0.65) | SLC6A4HTR1ATRPM8KDM4EMAPT | |
| SCHEMBL2478527 | 0.79 | SLC6A2 (0.72) | SLC6A4SLC6A2SLC6A3HTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1921859-A | Indole derivatives for the treatment of bone diseases | ASTELLAS PHARMA INC (JP) | 2007-02-28 | — | — | CN | disclosed |
| EP-1691807-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES | Astellas Pharma Inc. (JP) | 2006-08-23 | — | — | EP | disclosed |
| US-20050245540-A1 | New methods | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-03 | — | — | US | disclosed |
| WO-2005056012-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES | ASTELLAS PHARMA INC. (JP) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245540-A1 | New methods | TGFB1, TGFBR1, TGFB2 | HTR2C 1504/4885ADRB2 70/4885SLC6A4 1968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.