Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918957 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TDP1GLAPOLBL3MBTL1 | |
| SCHEMBL8997535 | 0.89 | NPFFR2 (0.45) | ALDH1A1TDP1GLAPOLBL3MBTL1 | |
| SCHEMBL8997541 | 0.89 | NPFFR2 (0.45) | ALDH1A1TDP1GLAPOLBL3MBTL1 | |
| SCHEMBL8879892 | 0.85 | GAA (0.43) | ALDH1A1TDP1GAAKDM4EMAPT | |
| SCHEMBL8879894 | 0.85 | GAA (0.43) | ALDH1A1TDP1GAAKDM4EMAPT | |
| SCHEMBL8120081 | 0.74 | NPFFR1 (0.45) | TDP1NOTUMGAAKDM4EMAPT | |
| SCHEMBL8034221 | 0.74 | NPFFR1 (0.45) | TDP1NOTUMGAAKDM4EMAPT | |
| SCHEMBL10747237 | 0.74 | THRB (0.47) | L3MBTL1KDM4EMAPTHTTGLO1 | |
| SCHEMBL9478271 | 0.74 | THRB (0.47) | L3MBTL1KDM4EMAPTHTTGLO1 | |
| SCHEMBL9478264 | 0.74 | THRB (0.47) | L3MBTL1KDM4EMAPTHTTGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670525-A | Substituted 4-phenyl-6-amino-nicotinic acid compounds useful in the treatment of CNS disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | disclosed |