SCHEMBL888000

SCHEMBL888000

COc1ccccc1C(c1ccccc1)(c1ccccc1OC)C(O)[C@H]1O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)C[C@@H]1O

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.43
PRMT6 Q96LA8 1/20 0.38
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
P2RY12 Q9H244 1/20 0.37
PAX8 Q06710 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5354472 0.97 ADORA3 (0.41) ADORA3PRMT6ADORA2AADORA1P2RY12
SCHEMBL7873199 0.92 PRMT6 (0.40) ADORA3PRMT6ADORA2AADORA1P2RY12
SCHEMBL888001 0.91 ADORA3 (0.45) ADORA3ADORA2AADORA1P2RY12
SCHEMBL2112346 0.89 ADORA3 (0.43) ADORA3ADORA2AADORA1P2RY12PAX8
SCHEMBL2112012 0.87 ADORA3 (0.43) ADORA3PRMT6P2RY12
SCHEMBL439195 0.87 PRMT5 (0.45) ADORA3ADORA2AP2RY12
SCHEMBL9773291 0.86 ADORA3 (0.40) ADORA3ADORA2AADORA1PAX8
SCHEMBL15954504 0.86 TYMP (0.38) ADORA3ADORA1PAX8
SCHEMBL7523809 0.85 PRMT5 (0.45) ADORA3ADORA2AP2RY12
SCHEMBL9015823 0.85 ADORA1 (0.44) ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2952587-B1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION STRATOS GENOMICS INC (US) 2023-07-05 EP disclosed
US-20180334729-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION Roche Sequencing Solutions, Inc. 2018-11-22 US disclosed
US-9920386-B2 High throughput nucleic acid sequencing by expansion STRATOS GENOMICS, INC. (US) 2018-03-20 US disclosed
US-20160208344-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION Roche Sequencing Solutions, Inc. 2016-07-21 US disclosed
EP-2952587-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION Stratos Genomics Inc. (US) 2015-12-09 EP disclosed
EP-2171088-B1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION STRATOS GENOMICS INC (US) 2015-10-14 EP disclosed
US-20130172197-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION STRATOS GENOMICS, INC. (US) 2013-07-04 US disclosed
US-8431366-B2 Modified oligonucleotides and applications thereof APPLIED BIOSYSTEMS, LLC (US) 2013-04-30 US disclosed
US-8349565-B2 High throughput nucleic acid sequencing by expansion STRATOS GENOMICS, INC. (US) 2013-01-08 US disclosed
US-8324360-B2 High throughput nucleic acid sequencing by expansion STRATOS GENOMICS, INC. (US) 2012-12-04 US disclosed
EP-0633890-B1 SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS ZENECA LTD (GB) 1998-09-09 EP disclosed
EP-0305201-B1 Protected biotin derivatives ZENECA LTD (GB) 1996-12-04 EP disclosed
US-5470967-A Hybridization probes to detect nucleic acid sequences THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1995-11-28 US disclosed
EP-0517796-B1 OLIGONUCLEOTIDE ANALOGS DU PONT MERCK PHARMA (US) 1995-04-19 EP disclosed
EP-0633890-A1 SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS ZENECA LIMITED (GB) 1995-01-18 EP disclosed
WO-1993020091-A1 SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS ZENECA LIMITED (GB) 1993-10-14 WO disclosed
EP-0517796-A1 OLIGONUCLEOTIDE ANALOGS. DU PONT (US) 1992-12-16 EP disclosed
WO-1991015500-A1 OLIGONUCLEOTIDE ANALOGS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO disclosed
EP-0202758-B1 HYBRIDIZATION METHOD AND PROBES THEREFOR Zeneca Limited (GB) 1991-09-25 EP disclosed
EP-0145486-A2 Microbiological process GLAXO GROUP LIMITED (GB) 1985-06-19 EP disclosed