Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27830260 | 0.81 | ALDH1A1 (0.35) | RAF1BRAFCBLBALDH1A1KDM4E | |
| SCHEMBL287556 | 0.79 | KDM4E (0.47) | ALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL578096 | 0.78 | KDM4E (0.46) | ALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL15356473 | 0.78 | KDM1A (0.41) | RAF1BRAFCBLBALDH1A1KDM4E | |
| SCHEMBL6844961 | 0.78 | CBLB (0.35) | RAF1BRAFCBLBALDH1A1KDM4E | |
| SCHEMBL3262633 | 0.78 | HTR2B (0.44) | CBLBALDH1A1KDM4EGAASMN1; SMN2 | |
| Lithium Ion SCHEMBL578095 | 0.76 | PTGER1 (0.36) | RAF1BRAFCBLBALDH1A1KDM4E | |
| Ethylene SCHEMBL27344274 | 0.76 | KDM4E (0.44) | ALDH1A1KDM4EGAASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL27830221 | 0.75 | KDM4E (0.35) | RAF1BRAFCBLBALDH1A1KDM4E | |
| SCHEMBL21538999 | 0.74 | GAA (0.36) | RAF1BRAFCBLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| EP-0239815-A1 | Substituted thiazoles and oxazoles, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-10-07 | — | — | EP | disclosed |