Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12293705 | 0.81 | ALDH1A1 (0.30) | ALDH1A1TSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2740778 | 0.78 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL9607597 | 0.78 | ALDH1A1 (0.32) | ALDH1A1TSHRMEN1KMT2ARIPK1 | |
| SCHEMBL20857549 | 0.76 | ALDH1A1 (0.30) | ALDH1A1TSHR | |
| SCHEMBL11809225 | 0.76 | KDM4E (0.36) | ALDH1A1TSHR | |
| SCHEMBL5264333 | 0.76 | ALDH1A1 (0.40) | ALDH1A1TSHRMEN1KMT2ARIPK1 | |
| SCHEMBL11621506 | 0.76 | ALDH1A1 (0.36) | ALDH1A1TSHRDRD4OPRM1DRD3 | |
| SCHEMBL20221015 | 0.74 | DRD4 (0.36) | DRD4OPRM1DRD3 | |
| SCHEMBL24351044 | 0.72 | DRD4 (0.32) | DRD4OPRM1DRD3 | |
| SCHEMBL16841724 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641778-A | EXHIBIT RENIN-INHIBITING PROPERTIES AND CAN BE USED AS ANTIHYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0716077-A1 | Aromatically substituted omega amino alcanoic acid amides and alcanoic diamides and their use as renine inhibitors | CIBA-GEIGY AG (CH) | 1996-06-12 | — | — | EP | disclosed |