Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880963 | 0.89 | CHRM2 (0.32) | ACACBHRH3 | |
| SCHEMBL8881673 | 0.89 | ADRB1 (0.33) | ACACBHRH3 | |
| SCHEMBL8880028 | 0.88 | ADRB1 (0.33) | HRH3 | |
| SCHEMBL9825901 | 0.88 | ACACB (0.32) | ACACBHRH3 | |
| SCHEMBL8880353 | 0.87 | MEN1 (0.32) | HRH3 | |
| SCHEMBL8880923 | 0.86 | MEN1 (0.40) | KCNH2 | |
| SCHEMBL8880142 | 0.85 | PPARG (0.33) | HRH3 | |
| SCHEMBL8881999 | 0.84 | PIK3CA (0.35) | HRH3 | |
| SCHEMBL8880246 | 0.83 | ALOX5AP (0.36) | ACACBHRH3 | |
| SCHEMBL9827236 | 0.83 | ALDH1A1 (0.45) | LTA4HPSMB1PSMB5PSMB2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| EP-0239815-A1 | Substituted thiazoles and oxazoles, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-10-07 | — | — | EP | disclosed |