Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880963 | 0.92 | CHRM2 (0.32) | ACACBCHRM2HTR1ADRD3HTR2B | |
| SCHEMBL8881673 | 0.90 | ADRB1 (0.33) | ACACBCHRM2HTR1ADRD3HTR2B | |
| SCHEMBL8880028 | 0.89 | ADRB1 (0.33) | CHRM2HTR1ADRD3HTR2BHRH3 | |
| SCHEMBL8881216 | 0.88 | HRH3 (0.35) | ACACBHRH3PPARGPPARAMEN1 | |
| SCHEMBL8880830 | 0.88 | LTA4H (0.39) | ACACBHRH3 | |
| SCHEMBL8880353 | 0.88 | MEN1 (0.32) | CHRM2HTR1ADRD3HTR2BHRH3 | |
| SCHEMBL8880923 | 0.87 | MEN1 (0.40) | CHRM2HTR1ADRD3HTR2BMEN1 | |
| SCHEMBL8880116 | 0.86 | ADRB2 (0.36) | PPARGPPARA | |
| SCHEMBL8880142 | 0.85 | PPARG (0.33) | CHRM2HTR1ADRD3HTR2BHRH3 | |
| Hydrochloric Acid SCHEMBL8880970 | 0.85 | ADRB2 (0.35) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| EP-0239815-A1 | Substituted thiazoles and oxazoles, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-10-07 | — | — | EP | disclosed |