Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882337 | 0.87 | SIGMAR1 (0.59) | ACACBSIGMAR1SLC6A4SLC2A1ADRB2 | |
| SCHEMBL8881084 | 0.83 | SLC2A1 (0.59) | ACACBSIGMAR1SLC6A4SLC2A1ADRB2 | |
| SCHEMBL9492053 | 0.78 | ADRB3 (0.50) | ACACBSIGMAR1SLC2A1ADRB2ADRB1 | |
| SCHEMBL9782119 | 0.78 | ACACB (0.72) | ACACB | |
| SCHEMBL256292 | 0.78 | ACACB (0.82) | ACACB | |
| SCHEMBL9782135 | 0.76 | ACACB (0.47) | ACACBSIGMAR1SLC2A1ADRB2ADRB1 | |
| SCHEMBL8879230 | 0.76 | ADRB2 (0.59) | ACACBSIGMAR1SLC6A4SLC2A1ADRB2 | |
| SCHEMBL27268878 | 0.76 | ACACB (0.51) | ACACBMEN1USP2ALDH1A1LMNA | |
| SCHEMBL10562624 | 0.75 | SLC6A4 (0.56) | ACACBSLC6A4 | |
| SCHEMBL8879792 | 0.75 | SLC6A4 (0.51) | ACACBSIGMAR1SLC6A4SLC2A1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |