Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.49 |
| ▸ | ACACB | O00763 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879230 | 0.85 | ADRB2 (0.59) | SLC6A4RAB9AADRB2ADRB3ADRB1 | |
| Hydrochloric Acid SCHEMBL10508646 | 0.83 | ACACB (0.47) | ADRB2ADRB3ADRB1ACACB | |
| SCHEMBL8882337 | 0.80 | SIGMAR1 (0.59) | SLC6A4ADRB2ADRB3ADRB1ACACB | |
| SCHEMBL8879908 | 0.79 | SLC6A4 (0.51) | SLC6A4ACACB | |
| SCHEMBL11245796 | 0.78 | ADRB3 (0.65) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| Hydrochloric Acid SCHEMBL10861241 | 0.78 | SLC6A4 (0.50) | SLC6A4ACACB | |
| SCHEMBL8881084 | 0.77 | SLC2A1 (0.59) | SLC6A4ADRB2ADRB3ADRB1ACACB | |
| SCHEMBL13290618 | 0.77 | KMT2A (0.59) | RAB9A | |
| SCHEMBL10860224 | 0.77 | ADRB3 (0.52) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| Hydrochloric Acid SCHEMBL10859952 | 0.76 | ADRB3 (0.52) | ADRB2ADRB3ADRB1CYP2D6ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |