Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 8/20 | 0.49 |
| ▸ | HTR3B | O95264 | 8/20 | 0.49 |
| ▸ | HTR3A | P46098 | 8/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 8/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 8/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.49 |
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563639 | 0.83 | TOP2A (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21208500 | 0.80 | KMT2A (0.47) | MAPK8TOP2AMKNK1MKNK2KAT2B | |
| SCHEMBL13082238 | 0.75 | RAD51 (0.41) | TOP2AGAAALPGTP53 | |
| SCHEMBL13056932 | 0.72 | KDM4E (0.48) | TOP2AGAA | |
| SCHEMBL21208499 | 0.71 | KDM4E (0.48) | MAPK8TOP2AMKNK1MKNK2GAA | |
| SCHEMBL13056890 | 0.71 | CSNK2A1 (0.60) | MAPK8TOP2ATP53 | |
| SCHEMBL8570625 | 0.68 | HTR3E (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1746874 | 0.67 | CYP2C19 (0.53) | TOP2AKAT2BGAAALPGCYP2C19 | |
| SCHEMBL8103067 | 0.67 | MAPK8 (0.73) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21208490 | 0.67 | KMT2A (0.48) | TOP2ATLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |