Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | PRKCB | P05771 | 3/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 9/20 | 0.49 |
| ▸ | CNR2 | P34972 | 9/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13131379 | 0.96 | GSK3B (0.51) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL22252332 | 0.86 | CNR2 (0.53) | GSK3BPRKCBCNR1CNR2HDAC3 | |
| SCHEMBL89569 | 0.82 | GSK3B (0.53) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL89559 | 0.81 | REN (0.51) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL13131380 | 0.80 | REN (0.57) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL13131352 | 0.78 | REN (0.52) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL13132295 | 0.78 | REN (0.48) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL88821 | 0.77 | CNR2 (0.57) | RENCNR1CNR2ALDH1A1 | |
| SCHEMBL13168767 | 0.77 | KDM4E (0.45) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL13131374 | 0.76 | CCNB2 (0.39) | GSK3BPRKCBCCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975252-B2 | Morpholine derivative | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | REN, AGTR1, AGTR2 | GSK3B 4814/4885PRKCB 3915/4885CCNB2 192/4885 |
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | GSK3B 4475/4885PRKCB 3900/4885CCNB2 2998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.