Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 13/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899662 | 0.91 | MAPT (0.49) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL4681858 | 0.88 | MAPT (0.46) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL5595825 | 0.81 | LMNA (0.52) | BCHEHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8882728 | 0.81 | POLB (0.42) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL4733026 | 0.80 | MAPT (0.59) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL26601857 | 0.78 | MAPT (0.47) | HTR1AL3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL1003702 | 0.77 | ACHE (0.37) | MAPTTDP1KDM4E | |
| SCHEMBL27277668 | 0.77 | SMN1; SMN2 (0.41) | L3MBTL1MAPTMAPK1KDM4E | |
| SCHEMBL21300617 | 0.76 | BCHE (0.67) | BCHEHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL27721108 | 0.75 | MAPT (0.56) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620995-A | Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |