Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881335 | 0.94 | TSHR (0.37) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8890841 | 0.92 | TSHR (0.35) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8881103 | 0.89 | HTT (0.35) | TSHRKDM4EALDH1A1HTTCCR4 | |
| SCHEMBL8883188 | 0.85 | NPSR1 (0.34) | TSHRPOLBSMN1; SMN2HTTCCR4 | |
| SCHEMBL8882800 | 0.84 | TSHR (0.32) | TSHR | |
| SCHEMBL7851095 | 0.82 | TSHR (0.36) | TSHRRAB9ACCR4SLC40A1 | |
| SCHEMBL8882454 | 0.79 | ALPL (0.36) | TSHRPOLBGAAHPGDMAPK1 | |
| SCHEMBL7853356 | 0.78 | TSHR (0.38) | TSHRKDM4EALDH1A1POLBGAA | |
| SCHEMBL7854314 | 0.78 | SLC40A1 (0.36) | TSHRALDH1A1SMN1; SMN2HSD17B10CCR4 | |
| SCHEMBL7848833 | 0.77 | SLC40A1 (0.35) | TSHRALDH1A1SMN1; SMN2HSD17B10CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614469-A | N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides | DOWELANCO (US) | 1997-03-25 | — | — | US | disclosed |
| EP-0717745-A1 | N-PYRIDINYL 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-06-26 | — | — | EP | disclosed |
| WO-1996001828-A1 | N-PYRIDINYL[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-01-25 | — | — | WO | disclosed |
| US-5461161-A | Chemical intermediate is 3-amino-2-hal pyridine | DOWELANCO (US) | 1995-10-24 | — | — | US | disclosed |