Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.63 |
| ▸ | ACHE | P22303 | 9/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116906 | 0.90 | CCR3 (0.67) | CCR3ACHEBCHEALDH1A1CXCR4 | |
| SCHEMBL3107807 | 0.90 | CCR3 (0.71) | CCR3ACHEBCHEALDH1A1CXCR4 | |
| SCHEMBL4499901 | 0.88 | CCR3 (0.69) | CCR3ACHEBCHEALDH1A1CXCR4 | |
| SCHEMBL4499239 | 0.88 | CCR3 (0.69) | CCR3ACHEBCHEALDH1A1CXCR4 | |
| SCHEMBL17262668 | 0.85 | DRD2 (0.68) | CCR3ACHEBCHEDRD2HTR2A | |
| SCHEMBL6847071 | 0.85 | CCR3 (0.70) | CCR3ACHEBCHEALDH1A1CXCR4 | |
| SCHEMBL15140944 | 0.84 | CCR3 (0.73) | CCR3ACHEBCHEALDH1A1CXCR4 | |
| SCHEMBL7371344 | 0.84 | SIGMAR1 (0.67) | CCR3ACHEBCHEDRD2HTR2A | |
| SCHEMBL8908408 | 0.84 | CCR3 (0.63) | CCR3ACHEBCHE | |
| SCHEMBL3457881 | 0.84 | CCR3 (0.63) | CCR3ACHEBCHEALDH1A1CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654306-A | ALZHEIMER'S DISEASE; COGNITION ACTIVATORS; BRAIN AND PSYCHOLOGICAL DISORDERS | EISAI CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| US-5424318-A | Piperidine derivative and pharmaceutical composition | EISAI CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5306720-A | Treatment of cerebrovascular disorders | EISAI CO., LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0229391-B1 | PIPERIDINE DERIVATE, ITS USE AND PHARMACEUTICAL COMPOSITION CONTAINING IT | Eisai Co., Ltd. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5118684-A | For cardiovascular disorder | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4942169-A | COGNITION ACTIVATORS, ANTICHOLINESTERASE | EISAI CO., LTD. (JP) | 1990-07-17 | — | — | US | disclosed |
| US-4849431-A | ANTICHOLINESTERASE ACTIVITY | EISAI CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0229391-A1 | Piperidine derivate, its use and pharmaceutical composition containing it | Eisai Co., Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |