Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882977 | 0.94 | PRKCA (0.45) | RXRAPRKCAPRKCDHPGDNPC1 | |
| SCHEMBL8881487 | 0.91 | RXRA (0.45) | RXRAPRKCAPRKCDHPGDNPC1 | |
| SCHEMBL8881217 | 0.90 | MRGPRX4 (0.47) | PRKCAPRKCDRAB9AMRGPRX4XDH | |
| SCHEMBL8883630 | 0.89 | RXRA (0.45) | RXRAPRKCAPRKCDHPGDNPC1 | |
| SCHEMBL8881921 | 0.84 | XDH (0.42) | PRKCAPRKCDXDHLMNA | |
| SCHEMBL8882103 | 0.83 | PRKCA (0.42) | PRKCAPRKCDLMNAKMT2A | |
| SCHEMBL8885505 | 0.83 | RXRA (0.43) | RXRAPRKCAPRKCDHPGDNPC1 | |
| SCHEMBL8881676 | 0.82 | PPIA (0.49) | RXRAHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8883500 | 0.81 | XDH (0.44) | MRGPRX4XDHLMNA | |
| SCHEMBL27404312 | 0.81 | TSHR (0.52) | RXRAHPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |