Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886758 | 0.87 | MAPT (0.51) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8883294 | 0.82 | MAPT (0.59) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8886016 | 0.80 | MAPT (0.51) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL6377084 | 0.79 | LMNA (0.58) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8885241 | 0.79 | ALDH1A1 (0.44) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8885497 | 0.77 | SMN1; SMN2 (0.52) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL471095 | 0.76 | MAPT (0.63) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7402604 | 0.75 | MAPT (0.66) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8886892 | 0.74 | CYP1A2 (0.48) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL27083133 | 0.74 | MAPT (0.52) | MAPTLMNAALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661169-A | HAVE AFFINITY FOR VASOPRESSIN AND/OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1997-08-26 | — | — | US | disclosed |
| US-5585394-A | INHIBITOR, ANTAGONIST OF VASOPRESSIN OR OXYTOCIN | SANOFI (FR) | 1996-12-17 | — | — | US | disclosed |
| EP-0694536-A1 | 1-Benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-01-31 | — | — | EP | disclosed |
| EP-0636614-A1 | Derivatives of 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-02-01 | — | — | EP | disclosed |