Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 7/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681700 | 0.88 | RXRA (0.50) | RXRAATM | |
| SCHEMBL27409127 | 0.87 | MRGPRX4 (0.54) | RXRANR4A2KDM5AKDM5BKDM4C | |
| SCHEMBL8882342 | 0.86 | ASPH (0.48) | RXRAKDM5AKDM4C | |
| SCHEMBL10530981 | 0.83 | RAB9A (0.54) | RXRAFFAR1KDM5AKDM5BKDM4C | |
| SCHEMBL4152950 | 0.80 | RAB9A (0.50) | RXRAFFAR1KDM5AKDM5BKDM4C | |
| SCHEMBL8883987 | 0.79 | KMT2A (0.56) | RXRANR4A2 | |
| SCHEMBL8882934 | 0.79 | MRGPRX4 (0.53) | KDM5BKDM4C | |
| SCHEMBL2241390 | 0.78 | MAPT (0.47) | KDM4C | |
| SCHEMBL4890014 | 0.77 | KDM4E (0.47) | RXRANR4A2 | |
| SCHEMBL5583635 | 0.77 | RXRA (0.50) | RXRAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |