Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | DPYD | Q12882 | 1/20 | 0.39 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1258908 | 0.90 | CRHBP (0.49) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL5117155 | 0.85 | CRHBP (0.54) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL27379385 | 0.81 | CRHBP (0.48) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL4488668 | 0.78 | CRHBP (0.58) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL9341183 | 0.77 | CRHBP (0.50) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL10750342 | 0.77 | CRHBP (0.50) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL11367725 | 0.77 | CRHBP (0.47) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL7378101 | 0.74 | CRHBP (0.50) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL7276657 | 0.72 | CRHBP (0.60) | CRHBPCRHR2ALDH1A1KDM4EHPGD | |
| SCHEMBL9846261 | 0.72 | CRHBP (0.49) | CRHBPCRHR2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-11-16 | — | — | US | disclosed |
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
| CN-109320499-B | Pyrrole-3-formamide compound and preparation method and application thereof | 沈阳药科大学 | 2020-09-08 | — | — | CN | disclosed |
| CN-109320499-A | Pyrrole-3-carboxamide class compound and its preparation method and application | 沈阳药科大学 | 2019-02-12 | — | — | CN | disclosed |
| US-5599823-A | HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-04 | — | — | US | disclosed |
| US-5356911-A | Hypotensive agents | BAYER AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| US-4451469-A | Selected 6-alkyl-and 4,6-dialkyl-2(1H)-pyridinones as cardiotonics | STERLING DRUG INC. (US) | 1984-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | USP28, USP30, USP8 | CRHBP 2041/4885CRHR2 4269/4885ALDH1A1 1934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.