Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456576 | 0.84 | NPBWR1 (0.53) | NPBWR1MCHR1CMA1 | |
| SCHEMBL29483303 | 0.82 | NPBWR1 (0.52) | NPBWR1MCHR1ALOX15CMA1 | |
| SCHEMBL6603633 | 0.82 | NPBWR1 (0.52) | NPBWR1MCHR1KDM4EALOX15 | |
| SCHEMBL13724241 | 0.81 | NPBWR1 (0.56) | NPBWR1MCHR1KDM4EALDH1A1MAPT | |
| SCHEMBL20745582 | 0.80 | NPBWR1 (0.51) | NPBWR1MCHR1KDM4EALDH1A1MAPT | |
| SCHEMBL2050022 | 0.79 | UCHL1 (0.57) | NPBWR1MCHR1KDM4EALDH1A1MAPT | |
| SCHEMBL27884414 | 0.79 | NPBWR1 (0.54) | NPBWR1MCHR1KDM4EALDH1A1MAPT | |
| SCHEMBL1048024 | 0.78 | NPBWR1 (0.48) | NPBWR1MCHR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18399187 | 0.78 | KDM4E (0.56) | NPBWR1MCHR1KDM4EALDH1A1MAPT | |
| SCHEMBL4680080 | 0.77 | NPBWR1 (0.47) | NPBWR1MCHR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631264-A | NEUROLOGICAL DISORDERS | SANOFI WINTHROP, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5554620-A | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof | STERLING WINTHROP INC. (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0656359-A1 | Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts and compositionsand methods of use thereof | STERLING WINTHROP INC. (US) | 1995-06-07 | — | — | EP | disclosed |