Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887601 | 0.78 | LMNA (0.48) | LMNAKMT2AMEN1NPC1KDM4E | |
| SCHEMBL8889377 | 0.78 | LMNA (0.48) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL8887257 | 0.73 | LMNA (0.52) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL8887376 | 0.73 | SMN1; SMN2 (0.70) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL17610298 | 0.71 | CYP1A2 (0.47) | KMT2AMEN1NPC1RAB9ACYP1A2 | |
| SCHEMBL7773183 | 0.71 | PTGS2 (0.61) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL7777871 | 0.70 | PTGS2 (0.58) | KMT2AMEN1 | |
| SCHEMBL8889051 | 0.70 | LMNA (0.60) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL8889515 | 0.70 | LMNA (0.53) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1376637 | 0.68 | LMNA (1.00) | LMNAKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997001551-A1 | PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-16 | — | — | WO | disclosed |