Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996516 | 0.77 | RPS6KA3 (0.47) | KMT2ASMN1; SMN2MEN1KDM4EALDH1A1 | |
| SCHEMBL17279842 | 0.77 | HPGD (0.45) | SMN1; SMN2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL11242632 | 0.75 | KDM4E (0.50) | LMNAKMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8888564 | 0.74 | ADORA3 (0.45) | KMT2ASMN1; SMN2MAPTMEN1KDM4E | |
| SCHEMBL9474883 | 0.74 | LMNA (0.81) | LMNAKMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL5216372 | 0.74 | CDK4 (0.50) | LMNAKMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22769602 | 0.73 | KDM4E (0.45) | LMNAKMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL8889764 | 0.73 | SMN1; SMN2 (0.51) | LMNAKMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL22784055 | 0.73 | MAP2K4 (0.49) | KMT2ASMN1; SMN2MAPTMEN1KDM4E | |
| SCHEMBL12567890 | 0.73 | ALDH1A1 (0.55) | SMN1; SMN2MAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997001551-A1 | PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-16 | — | — | WO | disclosed |