Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889764 | 0.87 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTMAP2K4CCNE2CDK4 | |
| SCHEMBL8889929 | 0.86 | MAPK13 (0.44) | SMN1; SMN2MAPK14MAP2K4CCNE2CDK4 | |
| SCHEMBL8889349 | 0.86 | ALDH1A1 (0.48) | SMN1; SMN2MAP2K4CCNE2CDK4CCND1 | |
| SCHEMBL17279847 | 0.85 | CCNE2 (0.45) | SMN1; SMN2MAPTMAP2K4CCNE2CDK4 | |
| SCHEMBL8888325 | 0.85 | IDO1 (0.49) | SMN1; SMN2MAPTMAPK14HTR7PIN1 | |
| SCHEMBL8889925 | 0.85 | MAP2K4 (0.45) | SMN1; SMN2MAPK14MAP2K4HTR7CCNE2 | |
| SCHEMBL8889130 | 0.83 | FGFR1 (0.47) | SMN1; SMN2MAP2K4CCNE2CDK4CCND1 | |
| SCHEMBL8889750 | 0.83 | GAA (0.48) | SMN1; SMN2MAPTMAPK14CSNK1DCDK2 | |
| SCHEMBL8889365 | 0.81 | IDO1 (0.49) | SMN1; SMN2MAPTMAPK14ALDH1A1RXRA | |
| SCHEMBL8887645 | 0.81 | RXRA (0.47) | SMN1; SMN2MAPTALDH1A1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997001551-A1 | PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-16 | — | — | WO | disclosed |