Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | FNTA | P49354 | 1/20 | 0.61 |
| ▸ | FNTB | P49356 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1519724 | 0.84 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7807900 | 0.83 | HRH3 (0.67) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31218207 | 0.83 | HRH3 (0.67) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1853622 | 0.83 | LMNA (0.71) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL947150 | 0.83 | MAPT (0.73) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7976825 | 0.83 | SMN1; SMN2 (0.71) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5803900 | 0.83 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1395865 | 0.83 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL468296 | 0.82 | LMNA (0.65) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29411993 | 0.82 | LMNA (0.65) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643903-A | PSYCOLOGICAL DISORDERS | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0481254-B1 | 2-(4-Piperidinyl)-1H-pyrido[4,3-b]indol-1 ones and related compounds, intermediates and a process for their preparation | HOECHST ROUSSEL PHARMA (US) | 1995-12-27 | — | — | EP | disclosed |
| US-5430038-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5430154-A | 2-(4-piperidinyl)-1H-pyrido[4,3-b]-indol-1-ones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5292883-A | Antipsychotics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-03-08 | — | — | US | disclosed |
| US-5229517-A | Intermediates for antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0481254-A2 | 2-(4-Piperidinyl)-1H-pyrido[4,3-b]indol-1 ones and related compounds, intermediates and a process for their preparation | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-22 | — | — | EP | disclosed |
| US-5102889-A | For treating psychosis | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | disclosed |