Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.58 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.58 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889424 | 0.91 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2NPC1RAB9AKMT2A | |
| SCHEMBL8890460 | 0.85 | CYSLTR1 (0.80) | CYSLTR1CYSLTR2PTGER4NPC1RAB9A | |
| SCHEMBL8829399 | 0.83 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2PTGER4ALOX5NPC1 | |
| SCHEMBL8829396 | 0.83 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2PTGER4ALOX5NPC1 | |
| SCHEMBL9146513 | 0.83 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2PTGER4ALOX5NPC1 | |
| SCHEMBL8889158 | 0.83 | LTB4R (0.44) | CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8888639 | 0.79 | CYSLTR1 (0.36) | CYSLTR1CYSLTR2 | |
| SCHEMBL8891776 | 0.79 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2PTGER4ALOX5 | |
| SCHEMBL8890576 | 0.77 | CYSLTR2 (0.35) | CYSLTR1CYSLTR2RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8890412 | 0.77 | LTB4R (0.53) | CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |