Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888639 | 0.85 | CYSLTR1 (0.36) | CYSLTR2CYSLTR1DRD2HTR2ALTB4R | |
| SCHEMBL8889600 | 0.85 | CYSLTR1 (0.50) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8889424 | 0.78 | CYSLTR1 (0.48) | CYSLTR2CYSLTR1ALOX5APKMT2ASMN1; SMN2 | |
| SCHEMBL8889206 | 0.77 | CYSLTR1 (0.58) | CYSLTR2CYSLTR1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL8890412 | 0.76 | LTB4R (0.53) | CYSLTR2CYSLTR1ALOX5APLTB4R | |
| SCHEMBL8889659 | 0.74 | LTB4R (0.44) | CYSLTR2CYSLTR1ALOX5APLTB4R | |
| SCHEMBL8889158 | 0.74 | LTB4R (0.44) | CYSLTR2CYSLTR1ALOX5APLTB4R | |
| SCHEMBL8890691 | 0.73 | ESR1 (0.47) | DRD2HTR2A | |
| SCHEMBL8889669 | 0.71 | CYSLTR1 (0.51) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8899272 | 0.69 | CYSLTR1 (0.49) | CYSLTR2CYSLTR1LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |