Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | HTR2B | P41595 | 7/20 | 0.39 |
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | HTR1D | P28221 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887028 | 0.89 | HTR2A (0.36) | HTR2CHTR2AHTR2BADRA2AADRA2C | |
| SCHEMBL4708565 | 0.78 | KDM4E (0.39) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL1143507 | 0.74 | HTR2C (0.45) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL8648210 | 0.74 | NOS3 (0.39) | HTR2CHTR2AHTR2BADRA2AADRA2C | |
| SCHEMBL10912069 | 0.66 | SRC (0.40) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL10912108 | 0.66 | SRC (0.40) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28633765 | 0.66 | MAOB (0.48) | HTR2CGAAMAPT | |
| SCHEMBL805990 | 0.64 | HTR2A (0.39) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL13035776 | 0.64 | HTR2C (0.43) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL29262572 | 0.64 | DRD2 (0.38) | ADRA2AADRA2CNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633276-A | MELATONIN SYSTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |