Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 9/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.37 |
| ▸ | FABP6 | P51161 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889464 | 0.78 | HTR2C (0.39) | HTR1AHTR2AHTR2CHTR2BNOTUM | |
| SCHEMBL4508514 | 0.74 | HTR1A (0.45) | KDM4EHTR1ASLC6A4PARP1PARP10 | |
| SCHEMBL4493259 | 0.71 | HTR1A (0.44) | KDM4EHTR1ASLC6A4PARP1PARP10 | |
| SCHEMBL1143507 | 0.70 | HTR2C (0.45) | HTR1AHTR2AHTR2CHTR2BHTR1D | |
| SCHEMBL4708855 | 0.69 | DYRK1A (0.40) | HTR1AFABP6PARP1PARP10PARP11 | |
| SCHEMBL4510164 | 0.69 | CYP1A2 (0.39) | KDM4EHTR1ASLC6A4PARP1PARP10 | |
| SCHEMBL8887028 | 0.67 | HTR2A (0.36) | KDM4EHTR2AHTR2CHTR2BMTNR1A | |
| SCHEMBL338965 | 0.67 | MTNR1A (0.44) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL12463566 | 0.67 | ACHE (0.50) | KDM4EFABP6PARP1PARP10PDPK1 | |
| SCHEMBL14206606 | 0.65 | HTR2A (0.34) | HTR1AHTR2AHTR2CHTR2BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893617-A1 | TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138549-A1 | TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS | WYETH (US) | 2006-12-28 | — | — | WO | claimed |