Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889154 | 0.87 | ACP1 (0.41) | MAP2K1KDM4ERAF1CYP3A4CYP2C9 | |
| SCHEMBL8888992 | 0.80 | CYSLTR1 (0.58) | MAP2K1 | |
| SCHEMBL14689917 | 0.71 | PTGS1 (0.63) | ALDH1A1HPGDSMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL8623799 | 0.70 | MAPT (0.45) | MTNR1AMTNR1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6474786 | 0.67 | LTB4R (0.41) | PTGS1PTGS2 | |
| SCHEMBL8889873 | 0.66 | CYP3A4 (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL19567186 | 0.66 | PTGS1 (0.63) | SMN1; SMN2MAPTPTGS1PTGS2 | |
| SCHEMBL8889251 | 0.66 | CYSLTR1 (0.38) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6479426 | 0.65 | KDM1A (0.43) | PTGS1PTGS2 | |
| SCHEMBL8888125 | 0.65 | CYP19A1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0665842-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008996-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1994-04-28 | — | — | WO | disclosed |