Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8624288 | 0.89 | HSPD1 (0.39) | MAPTTP53SMN1; SMN2PTGS1HSPD1 | |
| SCHEMBL8617759 | 0.82 | HSPD1 (0.37) | MAPTTP53SMN1; SMN2HSPD1HSPE1 | |
| SCHEMBL8623584 | 0.78 | THRA (0.49) | MAPTTP53SMN1; SMN2ALDH1A1HSPD1 | |
| SCHEMBL8666540 | 0.76 | MMP12 (0.36) | MAPTTP53SMN1; SMN2PTPN1HSPD1 | |
| SCHEMBL8619740 | 0.75 | VKORC1 (0.42) | MAPTSMN1; SMN2ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL8889871 | 0.70 | MAP2K1 (0.42) | MAPTSMN1; SMN2ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL15116359 | 0.70 | PTPN1 (0.73) | MAPTPPARASMN1; SMN2ALDH1A1PTPN1 | |
| SCHEMBL8666536 | 0.67 | MAPT (0.34) | MAPTTP53SMN1; SMN2HSPD1HSPE1 | |
| SCHEMBL8624230 | 0.66 | THRA (0.48) | MAPTTP53SMN1; SMN2POLB | |
| SCHEMBL6477257 | 0.65 | IDO1 (0.43) | MAPTPPARASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |