SCHEMBL8889902

SCHEMBL8889902

O=C1c2cc(O)ccc2OCC1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.44
EPHX2 P34913 1/20 0.36
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
SLC6A3 Q01959 2/20 0.33
HSP90AA1 P07900 2/20 0.33
HSP90AB1 P08238 2/20 0.33
LTB4R Q15722 1/20 0.32
LTB4R2 Q9NPC1 1/20 0.32
CYP19A1 P11511 1/20 0.32
DRD2 P14416 1/20 0.31
DRD3 P35462 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
CYP26A1 O43174 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8900137 0.84 MAOB (0.43) MAOBCYP3A4LTB4RLTB4R2ALDH1A1
SCHEMBL8891057 0.77 CYSLTR1 (0.54) MAOBEPHX2
SCHEMBL8889873 0.70 CYP3A4 (0.49) MAOBCYP3A4CYP19A1ALDH1A1MAPT
SCHEMBL8461434 0.68 MAOB (0.70) MAOBCYP3A4CYP19A1DRD2DRD3
SCHEMBL8465454 0.67 MAOB (0.56) MAOBCYP3A4CYP2D6SLC6A2SLC6A3
SCHEMBL8462840 0.66 CYP19A1 (0.60) MAOBCYP3A4CYP19A1ALDH1A1MAPT
SCHEMBL8890679 0.65 CYSLTR1 (0.38) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL8889605 0.65 LTB4R (0.54) LTB4RLTB4R2
SCHEMBL8890954 0.65 CYP19A1 (0.53) CYP3A4CYP2D6CYP19A1ALDH1A1MAPT
SCHEMBL8465206 0.65 MAOB (0.53) MAOBCYP3A4CYP19A1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5641789-A INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION PFIZER INC. (US) 1997-06-24 US disclosed
EP-0665842-A1 SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS PFIZER INC. (US) 1995-08-09 EP disclosed
WO-1994008996-A1 SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS PFIZER INC. (US) 1994-04-28 WO disclosed