Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889251 | 0.87 | CYSLTR1 (0.38) | CYSLTR1CYSLTR2CA2PTGS1PTGS2 | |
| SCHEMBL8900137 | 0.79 | MAOB (0.43) | CYSLTR1CYSLTR2CA2PTGS1PTGS2 | |
| SCHEMBL8889330 | 0.78 | CYSLTR1 (0.58) | CYSLTR1CYSLTR2 | |
| SCHEMBL8890954 | 0.72 | CYP19A1 (0.53) | CA2MAPTCYP3A4CYP2D6ESR1 | |
| SCHEMBL8889605 | 0.70 | LTB4R (0.54) | CYSLTR1CYSLTR2 | |
| SCHEMBL8890267 | 0.68 | CYP19A1 (0.50) | CA2PTGS1PTGS2KDM1ACA1 | |
| SCHEMBL8889873 | 0.68 | CYP3A4 (0.49) | CYSLTR1CYSLTR2PTGS1PTGS2MAPT | |
| SCHEMBL9200704 | 0.67 | CA2 (0.61) | CYSLTR1CYSLTR2CA2MAPTKDM1A | |
| SCHEMBL19567186 | 0.66 | PTGS1 (0.63) | CA2PTGS1PTGS2MAPTKDM1A | |
| SCHEMBL8889902 | 0.65 | MAOB (0.44) | MAPTCYP3A4CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0665842-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008996-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1994-04-28 | — | — | WO | disclosed |