Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.47 |
| ▸ | ESR1 | P03372 | 5/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888125 | 0.86 | CYP19A1 (0.56) | CYP19A1CYP26A1CYP24A1 | |
| SCHEMBL8900137 | 0.82 | MAOB (0.43) | ALDH1A1SMN1; SMN2TP53CYP3A4MAPT | |
| SCHEMBL8890267 | 0.80 | CYP19A1 (0.50) | CYP19A1CYP26A1ESR1ESR2CA2 | |
| SCHEMBL8890711 | 0.78 | LTB4R (0.40) | ESR1ESR2CYP3A4CA2 | |
| SCHEMBL8890710 | 0.78 | LTB4R (0.40) | ESR1ESR2CYP3A4CA2 | |
| SCHEMBL8465475 | 0.78 | CYP19A1 (0.78) | CYP19A1CYP26A1ESR1ESR2CYP24A1 | |
| SCHEMBL8890679 | 0.72 | CYSLTR1 (0.38) | ESR1CYP3A4CYP2D6MAPTCA2 | |
| SCHEMBL7745124 | 0.72 | CYP26A1 (0.66) | CYP19A1CYP26A1ESR1ESR2CYP24A1 | |
| SCHEMBL8892969 | 0.70 | CYSLTR2 (0.45) | MAPTCA2 | |
| SCHEMBL8892971 | 0.70 | CYSLTR2 (0.45) | MAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |