Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888895 | 0.77 | LTB4R (0.53) | CYP3A4CYP19A1 | |
| SCHEMBL8890711 | 0.75 | LTB4R (0.40) | ESR1ESR2HSD17B1STSCYP3A4 | |
| SCHEMBL8890710 | 0.75 | LTB4R (0.40) | ESR1ESR2HSD17B1STSCYP3A4 | |
| SCHEMBL8890975 | 0.74 | MGLL (0.49) | MAOA | |
| SCHEMBL10436270 | 0.74 | ESR1 (0.54) | ESR1ESR2HSD17B1STSDRD2 | |
| SCHEMBL10436404 | 0.74 | ESR1 (0.54) | ESR1ESR2HSD17B1STSDRD2 | |
| SCHEMBL8889659 | 0.73 | LTB4R (0.44) | — | |
| SCHEMBL8888639 | 0.73 | CYSLTR1 (0.36) | DRD2HTR2A | |
| SCHEMBL7246265 | 0.70 | LTB4R (0.43) | — | |
| SCHEMBL7249674 | 0.70 | BLM (0.41) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0665842-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008996-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1994-04-28 | — | — | WO | disclosed |