SCHEMBL8890748

SCHEMBL8890748

COCCc1ccc(Nc2nc(Nc3ccccc3)c3ccccc3n2)cc1

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 10/20 0.67
SLC2A1 P11166 2/20 0.56
MERTK Q12866 4/20 0.55
PIN1 Q13526 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8889582 0.93 NPY5R (0.76) NPY5RSLC2A1MERTK
SCHEMBL8891586 0.90 NPY5R (0.65) NPY5RSLC2A1MERTK
Hydrochloric Acid SCHEMBL8901384 0.89 NPY5R (0.64) NPY5RSLC2A1MERTK
SCHEMBL8891646 0.88 PIN1 (0.55) NPY5RSLC2A1MERTKPIN1
SCHEMBL8889731 0.85 NPY5R (0.59) NPY5RSLC2A1PIN1
SCHEMBL8889728 0.83 NPY5R (0.70) NPY5RSLC2A1
SCHEMBL8899488 0.83 NPY5R (0.69) NPY5RSLC2A1MERTK
Hydrochloric Acid SCHEMBL8900880 0.82 NPY5R (0.68) NPY5RSLC2A1MERTK
Hydrochloric Acid SCHEMBL8908244 0.82 NPY5R (0.68) NPY5RSLC2A1
SCHEMBL8890638 0.81 NPY5R (0.67) NPY5RMERTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997020822-A1 QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST NOVARTIS AG (CH) 1997-06-12 WO claimed
WO-1997020822-A1 QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST NOVARTIS AG (CH) 1997-06-12 WO disclosed