Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PPM1B | O75688 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369305 | 0.77 | KMT2A (0.52) | TDP1KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL8469278 | 0.76 | TDP1 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 | |
| SCHEMBL8891903 | 0.75 | PPM1B (0.46) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 | |
| SCHEMBL9644840 | 0.75 | KMT2A (0.49) | TDP1KMT2AMAPK1LMNAALDH1A1 | |
| SCHEMBL1021591 | 0.74 | TDP1 (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 | |
| SCHEMBL13286850 | 0.74 | PPM1B (0.56) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 | |
| SCHEMBL2432546 | 0.73 | MAPT (0.53) | TDP1KMT2AMAPK1LMNANPC1 | |
| SCHEMBL1088261 | 0.72 | TDP1 (0.45) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 | |
| SCHEMBL1087816 | 0.72 | TDP1 (0.45) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 | |
| SCHEMBL19841645 | 0.72 | CHRNB2 (0.51) | CHRNB2CHRNA5CHRNA7CHRNA4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997034891-A1 | SUBSTITUTED 1,3-THIAZOLIDINES AND 1,3-THIAZOLIDIN-4-ONES, METHOD FOR PREPARING SAME, AND USE THEREOF AS DRUGS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-09-25 | — | — | WO | disclosed |