Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888044 | 0.93 | KDM4E (0.47) | KDM4EASPHRIOX2KDM8SIGMAR1 | |
| SCHEMBL8893284 | 0.89 | HTR2C (0.43) | KDM4EASPHRIOX2KDM8SIGMAR1 | |
| SCHEMBL8890258 | 0.89 | CYP1A2 (0.47) | KDM4EASPHRIOX2KDM8SIGMAR1 | |
| SCHEMBL21045912 | 0.84 | TRPC6 (0.57) | KDM4EASPHRIOX2KDM8SIGMAR1 | |
| SCHEMBL10532890 | 0.83 | KDM4E (0.55) | KDM4EASPHRIOX2KDM8CYP1A2 | |
| SCHEMBL8890675 | 0.81 | CYP11B1 (0.50) | SIGMAR1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL8890275 | 0.80 | PDE4D (0.57) | — | |
| SCHEMBL21045700 | 0.78 | TRPC6 (0.54) | KDM4EASPHRIOX2KDM8TRPC6 | |
| SCHEMBL30439705 | 0.78 | TRPC6 (0.54) | KDM4EASPHRIOX2KDM8TRPC6 | |
| SCHEMBL8892821 | 0.78 | KDM4E (0.47) | KDM4EASPHKDM8CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |