Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891201 | 0.94 | CYP11B1 (0.45) | CYP11B1CYP11B2CHEK1RECQLL3MBTL1 | |
| SCHEMBL8891050 | 0.89 | CYP11B1 (0.47) | CYP11B1CYP11B2CHEK1RECQLL3MBTL1 | |
| SCHEMBL21045912 | 0.84 | TRPC6 (0.57) | CYP11B1CYP11B2TRPC6PDE4APDE4B | |
| SCHEMBL8889603 | 0.83 | ALDH1A1 (0.58) | CYP11B1CYP11B2L3MBTL1USP2ALDH1A1 | |
| SCHEMBL8891482 | 0.82 | PDE4D (0.52) | CYP11B1CYP11B2RECQLL3MBTL1USP2 | |
| SCHEMBL8891569 | 0.81 | KDM4E (0.52) | CYP11B1CYP11B2L3MBTL1ALDH1A1TRPC6 | |
| SCHEMBL8892821 | 0.80 | KDM4E (0.47) | CHEK1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL8889763 | 0.78 | PDE4A (0.61) | L3MBTL1USP2ALDH1A1NPSR1PDE4A | |
| SCHEMBL8890700 | 0.78 | ALDH1A1 (0.57) | CYP11B1CYP11B2L3MBTL1USP2ALDH1A1 | |
| SCHEMBL8888044 | 0.76 | KDM4E (0.47) | CYP11B1CYP11B2L3MBTL1ALDH1A1TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |