Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.49 |
| ▸ | PDE4A | P27815 | 8/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891681 | 0.90 | RAB9A (0.49) | RAB9ASMN1; SMN2NPC1PDE4BPDE4D | |
| SCHEMBL8890013 | 0.84 | KDM4E (0.61) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL8892194 | 0.84 | PDE4A (0.64) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL17844308 | 0.82 | KDM4E (0.61) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL8891479 | 0.81 | KDM4E (0.51) | SMN1; SMN2MAPTKDM4EPOLBCASP6 | |
| SCHEMBL8889771 | 0.80 | HPGD (0.47) | RAB9ASMN1; SMN2NPC1PDE4BPDE4D | |
| SCHEMBL14691415 | 0.77 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL4277044 | 0.76 | PDE4A (0.60) | RAB9ASMN1; SMN2NPC1PDE4BPDE4D | |
| SCHEMBL14705523 | 0.76 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL1029279 | 0.75 | PDE4A (0.59) | RAB9APDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |