Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | TPMT | P51580 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890013 | 0.95 | KDM4E (0.61) | KDM4EMAPTTSHRCA12CA1 | |
| SCHEMBL8891479 | 0.86 | KDM4E (0.51) | KDM4EMAPTTSHRTTRSYK | |
| SCHEMBL8891047 | 0.84 | SYK (0.62) | KDM4EMAPTTSHRCA12CA1 | |
| SCHEMBL8891275 | 0.84 | F10 (0.52) | KDM4EMAPTALDH1A1TDP1SYK | |
| SCHEMBL8892307 | 0.84 | KDM4E (0.52) | KDM4EMAPTALDH1A1TDP1SYK | |
| SCHEMBL8890956 | 0.84 | KDM4E (0.62) | KDM4EMAPTTSHRCA12CA1 | |
| SCHEMBL30622576 | 0.83 | PDE4A (0.65) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL17844309 | 0.83 | PDE4A (0.65) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL8891783 | 0.82 | RAB9A (0.50) | KDM4EMAPTSYKAURKBINCENP | |
| SCHEMBL8122418 | 0.81 | TSHR (0.78) | MAPTTSHRCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233847-A1 | AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex Suisse SA (CH) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016098005-A1 | AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2016-06-23 | — | — | WO | disclosed |