Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980704 | 0.84 | PRCP (0.39) | PLAUSIGMAR1 | |
| SCHEMBL5693079 | 0.77 | PLAU (0.60) | PLAUANPEPHTR1AGRIN2BMTNR1A | |
| SCHEMBL121704 | 0.72 | PDPK1 (0.43) | HTR1ASIGMAR1IDO1 | |
| SCHEMBL5256851 | 0.71 | PDPK1 (0.39) | SIGMAR1IDO1 | |
| SCHEMBL6026793 | 0.70 | SIGMAR1 (0.54) | HTR1ASIGMAR1 | |
| SCHEMBL1970744 | 0.69 | IDO1 (0.41) | SIGMAR1IDO1 | |
| SCHEMBL1383876 | 0.68 | ANPEP (0.39) | PLAUANPEPMTNR1AMTNR1BIDO1 | |
| SCHEMBL2183528 | 0.68 | PDPK1 (0.37) | PLAUMTNR1AMTNR1BMAOAMAOB | |
| SCHEMBL3653495 | 0.68 | PLAU (0.41) | PLAUANPEPGRIN2BIDO1 | |
| SCHEMBL8332242 | 0.68 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614497-A | TREATMENT OF HYPERTENSION, CARDIOVASCULAR DISEASE AND RENAL DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | claimed |