Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892879 | 0.82 | SLC6A3 (0.33) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8892302 | 0.78 | SIGMAR1 (0.51) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8892976 | 0.70 | SIGMAR1 (0.49) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8643721 | 0.69 | SIGMAR1 (0.66) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8642037 | 0.69 | LMNA (0.78) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8647649 | 0.69 | LMNA (0.83) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8645362 | 0.68 | LMNA (0.81) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL10551886 | 0.68 | SIGMAR1 (0.73) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL9430393 | 0.68 | SIGMAR1 (0.73) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8892780 | 0.67 | SIGMAR1 (0.55) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997027175-A1 | SUBSTITUTED ETHYL α,α - DIARYLMETHYL ETHER DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1997-07-31 | — | — | WO | claimed |
| WO-1997027175-A1 | SUBSTITUTED ETHYL α,α - DIARYLMETHYL ETHER DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1997-07-31 | — | — | WO | disclosed |