Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895981 | 0.81 | KDM4C (0.57) | KDM4CKMT2ASMN1; SMN2MEN1HSD17B10 | |
| Hydrochloric Acid SCHEMBL8894684 | 0.80 | KDM4C (0.56) | KDM4CKMT2ASMN1; SMN2MEN1HSD17B10 | |
| SCHEMBL14288498 | 0.77 | MAPT (0.37) | KMT2AMEN1GAAMAPTCYP1A2 | |
| SCHEMBL22870227 | 0.75 | MAPT (0.37) | KMT2AMEN1GAAMAPTCYP1A2 | |
| SCHEMBL8892830 | 0.73 | GAA (0.54) | KDM4CKMT2ASMN1; SMN2MEN1HSD17B10 | |
| SCHEMBL9731530 | 0.66 | KCNH2 (0.38) | KMT2AMEN1GAAMAPTCYP1A2 | |
| SCHEMBL8894176 | 0.66 | POLB (0.46) | KDM4CKMT2ASMN1; SMN2MEN1HSD17B10 | |
| SCHEMBL9378372 | 0.66 | HCN1 (0.46) | CYP1A2 | |
| Hydrochloric Acid SCHEMBL8892491 | 0.65 | POLB (0.45) | KDM4CKMT2ASMN1; SMN2MEN1HSD17B10 | |
| SCHEMBL8893610 | 0.65 | KDM4C (0.45) | KDM4CKMT2ASMN1; SMN2MEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654298-A | QUARTERNARY SALTS OF 4-AMINO-SUBSTITUTED PYRIDINES; MODULATORS OF THE SINOATRIAL NODE; CARDIOTONIC AND BRADYCARDIA AGENTS; | IMPERIAL CHEMICAL INDUSTRIES (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0453197-B1 | Amine derivatives | ICI PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| EP-0453197-A1 | Amine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-23 | — | — | EP | disclosed |