Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 3/20 | 0.31 |
| ▸ | RARB | P10826 | 3/20 | 0.31 |
| ▸ | RARG | P13631 | 3/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294272 | 0.78 | PDE4B (0.34) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8892652 | 0.77 | RARA (0.33) | CDC25ACDC25BRARARARBRARG | |
| SCHEMBL28222991 | 0.69 | RARA (0.37) | S100A4RARARARBRARGRXRA | |
| SCHEMBL28240052 | 0.69 | RARA (0.34) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL11821495 | 0.69 | S100A4 (0.34) | S100A4SOAT1MAP2K7CDC25ACDC25B | |
| Bromide SCHEMBL27553342 | 0.68 | PTPN1 (0.35) | RARARARBRARGCYP2C19 | |
| SCHEMBL9295862 | 0.66 | RARA (0.46) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL9296536 | 0.65 | TSHR (0.44) | RARARARBRARGCYP1A2CYP2C19 | |
| SCHEMBL5707360 | 0.63 | RARB (0.50) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL21538692 | 0.63 | RARA (0.39) | RARARARBRARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |