Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9065218 | 1.00 | LMNA (0.68) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL30228454 | 1.00 | LMNA (0.68) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL23843550 | 0.98 | ADRB1 (0.69) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL29058159 | 0.94 | ADRB1 (0.69) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL28762158 | 0.89 | MEN1 (0.61) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL11067105 | 0.89 | ADRB1 (0.74) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL31468714 | 0.83 | ADRB1 (0.64) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL329640 | 0.83 | ADRB1 (0.64) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL2332676 | 0.83 | ADRB1 (0.64) | LMNAMEN1KMT2AADRB1ALDH1A1 | |
| SCHEMBL329728 | 0.83 | ADRB1 (0.64) | LMNAMEN1KMT2AADRB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023202705-A1 | OPHTHALMIC PREPARATION AND APPLICATION THEREOF IN TREATING PRESBYOPIA | 温州医科大学附属眼视光医院 | 2023-10-26 | — | — | WO | disclosed |
| US-9181245-B2 | Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease | Janssen Pharmaceuticals, Inc. (US) | 2015-11-10 | — | — | US | disclosed |
| US-9181245-B2 | Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease | Janssen Pharmaceuticals, Inc. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20150141411-A1 | SUBSTITUTED 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONE DERIVATIVES USEFUL FOR THE TREATMENT OF (INTER ALIA) ALZHEIMER'S DISEASE | CELLZOME LIMITED (GB) | 2015-05-21 | — | — | US | disclosed |
| US-20150141411-A1 | SUBSTITUTED 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONE DERIVATIVES USEFUL FOR THE TREATMENT OF (INTER ALIA) ALZHEIMER'S DISEASE | CELLZOME LIMITED (GB) | 2015-05-21 | — | — | US | disclosed |
| CN-100469837-C | Fire-retardant resin composition and its molded product | GEN ELECTRIC (NL) | 2009-03-18 | — | — | CN | disclosed |
| CN-1234758-C | Incombustible resin composition and molded article thereof | GEN ELECTRIC (US) | 2006-01-04 | — | — | CN | disclosed |
| CN-1487968-A | Flame retardant resin compositon and molded products thereof | ͨ�õ�����˾ | 2004-04-07 | — | — | CN | disclosed |
| CN-1370803-A | Fire-retardant resin composition and its molded product | GEN ELECTRIC (US) | 2002-09-25 | — | — | CN | disclosed |
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141411-A1 | SUBSTITUTED 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONE DERIVATIVES USEFUL FOR THE TREATMENT OF (INTER ALIA) ALZHEIMER'S DISEASE | BACE1, PSEN1, BACE2 | LMNA 772/4885MEN1 3484/4885KMT2A 2505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.