Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897017 | 0.73 | FDPS (0.41) | RENALDH1A1 | |
| SCHEMBL3615864 | 0.72 | GABRA5 (0.48) | GABRA5GABRB2HSD17B10ALDH1A1NPC1 | |
| SCHEMBL8254599 | 0.70 | GABRA5 (0.47) | GABRA5GABRB2HSD17B10RENALDH1A1 | |
| SCHEMBL5869739 | 0.70 | GABRA5 (0.47) | GABRA5GABRB2HSD17B10RENALDH1A1 | |
| SCHEMBL9864531 | 0.69 | HSD17B10 (0.56) | GABRA5GABRB2HSD17B10ALDH1A1NPC1 | |
| SCHEMBL27391773 | 0.68 | GABRA5 (0.50) | GABRA5GABRB2HSD17B10ALDH1A1NPC1 | |
| SCHEMBL8955092 | 0.65 | HSD17B10 (0.59) | GABRA5GABRB2HSD17B10ALDH1A1RAB9A | |
| SCHEMBL30583244 | 0.65 | GABRA5 (0.46) | GABRA5GABRB2HSD17B10ALDH1A1NPC1 | |
| SCHEMBL28694718 | 0.65 | HSD17B10 (0.59) | GABRA5GABRB2HSD17B10ALDH1A1RAB9A | |
| SCHEMBL1081994 | 0.65 | GABRA5 (0.54) | GABRA5GABRB2HSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693619-A | ENZYME INHIBITORS; ADMINISTERED TO TREAT CONGESTIVE HEART FAILURE AND HYPERTENSION | BOEHRINGER INGELHEIM (CANADA), LTD. (CA) | 1997-12-02 | — | — | US | claimed |