Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 5/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304172 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSLCTSBCTSKACE | |
| SCHEMBL9337020 | 0.84 | CTSL (0.43) | CTSLCTSBCTSKMME | |
| SCHEMBL8894558 | 0.82 | MME (0.48) | SMN1; SMN2ACEMMEMEN1NPC1 | |
| SCHEMBL8733280 | 0.82 | MME (0.48) | SMN1; SMN2ACEMMEMEN1NPC1 | |
| SCHEMBL9753834 | 0.80 | MME (0.40) | CTSLCTSBCTSKMME | |
| SCHEMBL18065697 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2MEN1NPC1KMT2ALMNA | |
| SCHEMBL27636583 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CTSKACEMEN1NPC1 | |
| SCHEMBL18085413 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1NPC1KMT2AMAPT | |
| SCHEMBL7412656 | 0.74 | L3MBTL1 (0.39) | CTSLCTSBCTSK | |
| SCHEMBL18065695 | 0.74 | EPHX2 (0.54) | SMN1; SMN2MEN1NPC1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010644-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |