Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.66 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.62 |
| ▸ | CTSD | P07339 | 2/20 | 0.61 |
| ▸ | REN | P00797 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894396 | 0.90 | REN (0.67) | BACE1BACE2CTSDREN | |
| SCHEMBL10790323 | 0.87 | BACE1 (0.60) | BACE1BACE2CTSD | |
| SCHEMBL29601744 | 0.85 | BACE1 (0.60) | BACE1BACE2CTSD | |
| SCHEMBL30886676 | 0.84 | BACE1 (0.88) | BACE1BACE2CTSD | |
| SCHEMBL10749186 | 0.83 | REN (0.61) | BACE1BACE2CTSDREN | |
| SCHEMBL8893459 | 0.83 | REN (0.61) | BACE1BACE2CTSDREN | |
| SCHEMBL28860411 | 0.82 | LTA4H (0.64) | — | |
| SCHEMBL29519583 | 0.82 | LTA4H (0.64) | — | |
| SCHEMBL2185269 | 0.82 | LTA4H (0.64) | — | |
| SCHEMBL1864709 | 0.82 | LTA4H (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | claimed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | claimed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | claimed |
| US-5688770-A | RENIN INHIBITOR AND BETA ADRENERGIC BLOCKING AGENT | SCHERING CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| US-5352666-A | Using a renin inhibitor | SCHERING CORPORATION (US) | 1994-10-04 | — | — | US | disclosed |
| WO-1992013564-A1 | COMBINATION OF AN ANGIOTENSIN II ANTAGONIST OR RENIN INHIBITOR WITH A NEUTRAL ENDOPEPTIDASE INHIBITOR | SCHERING CORPORATION (US) | 1992-08-20 | — | — | WO | disclosed |
| EP-0498361-A2 | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor | SCHERING CORPORATION (US) | 1992-08-12 | — | — | EP | disclosed |
| EP-0246381-B1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4906613-A | Antiglaucoma compositions and methods | SCHERING CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0246381-A1 | Renin inhibitors and methods for using same | SCHERING CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | disclosed |