SCHEMBL8895421

SCHEMBL8895421

O=C(O)c1ccc2ccccc2c1OS(=O)(=O)C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 1/20 0.50
LDHA P00338 1/20 0.49
NR4A1 P22736 1/20 0.45
NR4A2 P43354 1/20 0.45
NR4A3 Q92570 1/20 0.45
CDC25B P30305 1/20 0.41
CYP1A1 P04798 1/20 0.40
CYP1B1 Q16678 1/20 0.40
RAB9A P51151 2/20 0.39
PKM P14618 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
HPGD P15428 3/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
CYP2D6 P10635 1/20 0.38
CSNK2A2 P19784 1/20 0.38
CSNK2B P67870 1/20 0.38
CSNK2A1 P68400 1/20 0.38
PFKFB3 Q16875 1/20 0.38
KDM4E B2RXH2 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17836993 0.89 HSD11B1 (0.46) WDR5LDHACYP1A1CYP1B1RAB9A
SCHEMBL254145 0.86 HDAC3 (0.48) WDR5CYP1A1CYP1B1RAB9AHPGD
SCHEMBL17841056 0.83 CDC25B (0.49) CDC25BRAB9AHPGDALDH1A1KDM4E
SCHEMBL7197168 0.82 ERN1 (0.44) HPGDALDH1A1KDM4EMEN1MAPT
SCHEMBL7599032 0.81 DNMT1 (0.39) RAB9AHPGDALDH1A1KDM4EMEN1
SCHEMBL19949358 0.80 SLC2A1 (0.36) HPGDALDH1A1KDM4EMEN1MAPT
SCHEMBL7709361 0.80 MAPT (0.37) RAB9AHPGDALDH1A1KDM4EMEN1
SCHEMBL29428610 0.80 SLC2A1 (0.36) HPGDALDH1A1KDM4EMEN1MAPT
SCHEMBL485270 0.79 CXCR2 (0.46) CYP1A1CYP1B1RAB9AHPGDALDH1A1
SCHEMBL14059189 0.79 ALOX15 (0.44) NR4A1NR4A2NR4A3HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018005249-A1 BENZOISOQUINOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS MERCK SHARP & DOHME CORP. (US) 2018-01-04 WO disclosed
WO-2017160670-A1 M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF MERCK SHARP & DOHME CORP. (US) 2017-09-21 WO disclosed
WO-1997048672-A2 SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY ALLERGAN SALES, INC. (US) 1997-12-24 WO disclosed