Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8610388 | 0.86 | ABHD6 (0.56) | ABHD6MAPTMEN1KMT2ATAAR1 | |
| SCHEMBL8896153 | 0.83 | CACNA1B (0.46) | MAPTTDP1MEN1KMT2ANPC1 | |
| SCHEMBL8531114 | 0.83 | CACNA1B (0.46) | MAPTTDP1MEN1KMT2ANPC1 | |
| SCHEMBL8898649 | 0.83 | CACNA1B (0.46) | MAPTTDP1MEN1KMT2ANPC1 | |
| SCHEMBL324228 | 0.81 | TMEM97 (0.67) | TMEM97SIGMAR1MEN1KMT2APRMT5 | |
| SCHEMBL3898451 | 0.79 | ABHD6 (0.42) | RECQLTMEM97SIGMAR1ABHD6MAPT | |
| SCHEMBL3898458 | 0.79 | CTSS (0.56) | PSMB1PSMB2 | |
| SCHEMBL8895899 | 0.77 | ABHD6 (0.49) | ABHD6MAPTMEN1KMT2ATAAR1 | |
| SCHEMBL6102363 | 0.76 | ABHD6 (0.68) | ABHD6MAPTTDP1MEN1KMT2A | |
| SCHEMBL9358821 | 0.75 | MEN1 (0.42) | TMEM97SIGMAR1MAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |