Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSH | P09668 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16732152 | 0.85 | METAP2 (0.43) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL16732255 | 0.83 | METAP2 (0.41) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL7293924 | 0.82 | METAP2 (0.35) | METAP2 | |
| SCHEMBL10959631 | 0.81 | METAP2 (0.56) | METAP2METAP1MMP2EPHX1 | |
| SCHEMBL10959638 | 0.81 | METAP2 (0.56) | METAP2METAP1MMP2EPHX1 | |
| Hydrochloric Acid SCHEMBL10523043 | 0.81 | METAP2 (0.46) | METAP2METAP1MMP1MMP2MMP3 | |
| Hydrochloric Acid SCHEMBL10523064 | 0.81 | METAP2 (0.46) | METAP2METAP1MMP1MMP2MMP3 | |
| SCHEMBL8745902 | 0.79 | METAP1 (0.46) | METAP2METAP1EPHX1 | |
| SCHEMBL8745887 | 0.79 | METAP1 (0.42) | METAP2METAP1EPHX1SMN1; SMN2 | |
| SCHEMBL8201992 | 0.77 | METAP2 (0.42) | METAP2METAP1MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693619-A | ENZYME INHIBITORS; ADMINISTERED TO TREAT CONGESTIVE HEART FAILURE AND HYPERTENSION | BOEHRINGER INGELHEIM (CANADA), LTD. (CA) | 1997-12-02 | — | — | US | disclosed |